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Covid Botswana ‘super variant’ found with ‘horrific’ 32 mutations

A new Covid-19 variant is believed to be the “most evolved strain” of the virus and could be escaping existing vaccinations, scientists have warned.

The B.11.529 variant has an “extremely high number” of mutations and is believed to have first emerged in Botswana with cases now being identified in South Africa and Hong Kong.

Despite just 10 cases of the mutated virus being found so far through genomic sequencing, experts believe its identification in three countries suggest it is more widespread, reports The Mirror.

It has 32 mutations in total and scientists worry the virus has mutated enough to escape the effectiveness of current vaccines, helping it evade immunity.

The identification of one case in Hong Kong came after a passenger travelled from South Africa. This has sparked fear that infection could be spreading through international travel.

Dr Tom Peacock, a virologist at Imperial College who tweeted about the find, described the variant’s combination of mutations as “horrific”.

A new Covid-19 variant is believed to be the “most evolved strain” of the virus

Describing the new strain’s mutation profile as “really awful”, he added that it had the potential to be “worse than nearly anything else about”, including the now-dominant Delta strain, which has 16 spike mutations.

He wrote: “Export to Asia implies this might be more widespread than sequences alone would imply. Also the extremely long branch length and incredibly high amount of spike mutations suggest this could be of real concern (predicted escape from most known monoclonal antibodies).

“Worth emphasising this is at super low numbers right now in a region of Africa that is fairly well sampled, however it very very much should be monitored due to that horrific spike profile (would take a guess that this would be worse antigenically than nearly anything else about).”

So far, three cases have been detected in Botswana and six in South Africa. The first cases were collected in Botswana on 11 November.

The Hong Kong case was a 36-year-old man who travelled to South Africa on 23 October and returned on 11 November.

He tested negative on his return to Hong Kong but went on to test positive on 13 November while undergoing quarantine at a hotel.

In South Africa, cases rose from 312 on Monday to more than 860 on Tuesday but scientists believe it is too soon to tell whether there is a link with the new “super variant”.

A medical worker prepares a syringe with a vaccine against the novel coronavirus COVID-19
There are concerns that the new variant will evade existing immunity.

New coronavirus variants are identified all the time and often will not spread beyond a handful of cases.

There are currently no cases of the B.1.1.529 variant in the UK but officials and scientists at the UK Health Security Agency (UKHSA) said they were monitoring and investigating the variant.

Dr Meera Chand, Covid-19 Incident Director at UKHSA, said: “The UK Health Security Agency, in partnership with scientific bodies across the globe, is constantly monitoring the status of SARS-CoV-2 variants as they emerge and develop worldwide.

“As it is in the nature of viruses to mutate often and at random, it is not unusual for small numbers of cases to arise featuring new sets of mutations. Any variants showing evidence of spread are rapidly assessed.”

Professor Francois Balloux, director of the University College London’s Genetics Institute, said the variant may have evolved during a chronic infection in an immunocompromised person, possibly an untreated HIV/Aids patient.

He said: “I would definitely expect it to be poorly recognised by neutralising antibodies relative to Alpha or Delta.

“It is difficult to predict how transmissible it may be at this stage. For the time being, it should be closely monitored and analysed, but there is no reason to get overly concerned, unless it starts going up in frequency in the near future.”

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